Drug Discovery Using the iEM Platform
Creative Biostructure offers a unique integrated platform for electron microscopy (iEM Platform). We focus on materials characterization and morphology, which can play a critical role in drug discovery efforts. With the help of our advanced platform and professional experts, biomedical researchers can discover and identify various compounds with medical bearing. Then, these candidate drugs can be designed and used for a wide array of applications.
Drug Discovery
Drug discovery is a complex, expensive and long process. With the development of biomolecular structure determination methods, the completion of the Human Genome Project as well as the progress of bioinformatics, the pace of drug discovery is greatly accelerated. During the process of drug discovery (ranging from drug target identification to lead optimization), the information of the three-dimensional structure of macromolecular drug targets and their ligands is important. Based on our iEM Platform including cryo-electron microscopy (cryo-EM), we are able to interpret complex protein structures and offer structure-based drug discovery and design.
Structure-Based Drug Discovery
Compared to traditional drug discovery methods, structure-based drug discovery is faster, more economical, and more efficient. Thanks to the combination of cutting-edge achievements of multiple disciplines, such as structural biology and computational chemistry, structure-based drug discovery technology starts with the structure of the identified target protein and can perform large-scale virtual compound library screening and small molecule structure design. In addition, structure-based drug discovery technology can not only be applied to predict potential targets but also identify new uses for current drugs. Our cryo-EM analysis technology is in the leading position in the world. The high resolution, nearly natural, fully hydrated protein structure provides a breakthrough for structure-based drug discovery.
Our Capability
Creative Biostructure is a reliable and professional partner in the drug discovery industry. With world-leading facilities that combine cutting-edge technology, our unique platform facilitates drug discovery for multiple drug target structures. We are dedicated to providing high-resolution images of a wide array of samples, enabling medical researchers and professionals to obtain higher productivity and better conclusions.
Screen hundreds of compounds.
Automated data collection and highly streamlined data processing.
Membrane protein characterization, such as ion channels, G protein-coupled receptors (GPCR), transmembrane proteins and difficult-to-crystalize complexes.
Protein characterization, involving protein conformation, conformational changes, and oligomeric states.
Why Choose Us?
Customization
We offer a customized end-to-end solution to fulfil clients’ R&D and manufacturing requirements.Innovation
At iEM Platform, we continually evaluate and embrace new technologies to enhance our service offering.Thoughtful Services
Our customer service representatives are available 24 hours a day from Monday to Sunday.
If you are interested in our services, please contact us for more details.
Robertson, M. J., et al. (2021). "Drug discovery in the era of cryo-electron microscopy." Trends in Biochemical Sciences.
García-Nafría, J., & Tate, C. G. (2020). "Cryo-electron microscopy: moving beyond X-ray crystal structures for drug receptors and drug development." Annual review of pharmacology and toxicology, 60, 51-71.
